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KMID : 0644120090220030099
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Journal of Oriental Gynecology
2009 Volume.22 No. 3 p.99 ~ p.116
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Comparative Study on Anti-thrombotic Effects of Gamihyunbooleekyungtang with Decoction Method
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Jeong Ji-Hye
Lee Soon-Yee
Jang Yun-Jeong
Choe Chang-Min
Cho Han-Baek
Kim Song-Baek
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Abstract
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Purpose: In this study, we investigated anti-thrombotic effects of Gamihyunbooleekyungtang currently used clinical treatment of dysmenorrhea and compared effects by decoction methods.
Methods: Gamihyunbooleekyungtang was extracted by pressure extractor (GHYT) and nonpressure extractor(GHYT-1). Inhibitory effect of platelet cohesion, suppression effect of GPIIb/IIIa activity, inhibitory effect of and biosynthesis, and oxidative damage suppression effect were tested in vitro. Also suppression of pulmonary embolism was studied in vivo.
Results: In this study, both GHYT and GHYT-1 extract showed a safety in cytotoxicity of hFCs. Both showed dose-dependent inhibitory effect on platelet coagulation. GHYT-1 extract is usually higher than GHYT, especially for . GHYT and GHYT-1 extract showed dose-dependent inhibitory effect on GPIIb/IIIa activities. GHYT extract suppressed significantly biosynthesis at 1000, 500 and also suppressed significantly biosynthesis at 1000 as compared with the control group. GHYT-1 suppressed significantly biosynthesis at 1000 as compared with the control group. Also it suppressed pulmonary embolism triggered by collagen and epinephrine by respectively 50%, 75% as compared with the control group. Both GHYT and GHYT-1 extract showed dose-dependent decrease of oxidative damages caused by DPPH, whereas dose-dependent increase of superoxide dismutase like activity was observed.
Conclusion: These results suggest that Gamihyunbooleekyungtang can be used for treating dysmenorrhea caused by thrombosis. Nonpressure decoction method is a little more effective, but more detailed studies would be needed.
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KEYWORD
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Gamihyunbooleekyungtang(GHYT), anti-thrombosis, dysmenorrhea, decoction method
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